Another recent study showed that somatic SVs enriched for enhancer hijacking also play a major role in shaping the cancer DNA methylome and regulating the expression of nearby genes, such as MYC, MYCN, TERT, ZFTA, KIAA1549, ATRX, and CDKN2A, in pediatric brain tumors (154). The gene discussed is CDKN2A; the disease is cancer.