Additionally, H3K27me3 demethylase UTX/KDM6 plays crucial roles in GNP differentiation through NEUROD2 expression and recruits immune cells to the tumor microenvironment, thereby UTX/KDM6A deletion contributes to SHH-MB development by maintaining undifferentiated and immunologically cold states (67). The gene discussed is KDM6A; the disease is neoplasm.