SOX9 suppresses high grade glioma (HGG) growth and expands acetylation of histone H3 at lysine 27 (H3K27ac), but facilitates zinc finger translocation-associated (ZFTA) fusion-positive supratentorial ependymoma (ST-EPN-ZFTA) development by altering H3K27ac occupancy (48). The gene discussed is MME; the disease is ependymoma.