This study aimed to identify cytotoxic T lymphocyte (CTL)-specific epitopes from three tumor-associated antigens (TAAs)—Dickkopf-like 1 (DKKL1), F-box protein 39 (FBXO39), and Opa-interacting protein 5 (OIP5)—which are overexpressed in colorectal cancer (CRC), as potential candidates for CTL-mediated immunotherapy. This evidence concerns the gene FBXO39 and colorectal cancer.