Another study compared the cytokine response (e.g., TNF, IL-6, IL-10, IL-8, MIP-1, MCP-1) in plasma at baseline before CRS, after CRS, after HIPEC (oxaliplatin in dextrose 5 %, 30 min, 42–43 °C), and postoperatively in 20 patients, which showed significantly increased levels among all investigated cytokines in plasma during CRS followed by a minor and non-significant increase during HIPEC [40]. This evidence concerns the gene CCL2 and congenital rubella syndrome.