Conversely, AKAP9’s binding to PP1 leads to the dephosphorylation of KCNQ1, and mutations within this complex have been implicated in type 1 long QT syndrome (LQT1), a potentially fatal inherited arrhythmia syndrome (Marx et al., 2002; Chen and Kass, 2011; Chen and Kass, 2006; Morgat et al., 2024) (Figure 3). The gene discussed is AKAP9; the disease is long QT syndrome 1.