The mAKAPβ/PLCε/PKD and AKAP-Lbc/PKD/HDAC5 pathways play a critical role in regulating myocardial hypertrophy, considerably contributing to the progression of heart failure (Zhang et al., 2013; Vergarajauregu et al., 2020; He et al., 2020; Appert-Collin et al., 2007; Kilian et al., 2021; Carnegie et al., 2008). Here, PRKD1 is linked to heart failure.