Pathway enrichment analysis indicated that Endothelin-1(EDN1)+CCL2+ endothelial subsets were primarily involved in inflammatory signaling cascades, including TNF-α and interferon-γ (IFN-γ) pathways, whereas tumor-associated endothelial populations exhibited upregulation of biosynthetic and metabolic pathways related to angiogenesis and stromal remodeling (Xing et al., 2021). Here, EDN1 is linked to neoplasm.