NF-κB regulates genes involved in cell proliferation (Cyclin D1), anti-apoptosis (e.g., survivin and the inhibitor of apoptosis protein), anti-cancer drug resistance (MDR1), cancer metastasis (e.g., COX-2 and MMP9), and immunomodulation (Takada et al., 2005). The gene discussed is PROS1; the disease is cancer.