OPTN and intrahepatic cholangiocarcinoma: As shown in Figure 5, before NDP52, OPTN, NBR1, and p62 gene knockdown, unlike in the GA group, the expression level of the pS757-ULK1 protein in ICC was significantly reduced, and the expression level of the pS757-ULK1 protein in the GA + NAR group was noticeably decreased (p < 0.01) (Figures 5A,B).