In the rHuPDGF-BB-induced human KRASG12C-mutant NSCLC cell lines H358 and H2122, the phosphorylation of SRC, C-RAF, MEK1/2, and ERK1/2 and the expressions of Ras, JUNB, FOSB and PD-L1 were clearly inhibited by increasing concentrations of tricin. Here, MAP2K1 is linked to non-small cell lung carcinoma.