Further mechanistic investigations have revealed that hypoxia activated C-X-C Motif Chemokine Receptor 1/2 (CXCR1/2), leading to the activation of JAK/STAT1 pathway, which subsequently triggered the secretion of IL-10 to facilitate macrophages polarization towards M2 phenotype, further established a reciprocal loop between TAMs and tumor cells (Piao et al., 2022). The gene discussed is IL10; the disease is neoplasm.