TRAF6 and gastric cancer: High expression of CCL2 was found to be associated with increased the proportion of M2-like phenotype macrophages, which could be attributed to activated ZC3H12A-TRAF6/3 axis, which could be reversed by CD40-HER2 bispecific antibody that recovered the ubiquitination process of TRAF6/3, leading to decreased M2-like TAMs in the TIME of HER2-positive GC (Sun et al., 2022).