Mechanistically, exosomal miR-20b-5p, miR-17-5p, and miR-93-5p transcriptionally and translationally reduced PD-L1 levels in TAMs, which facilitated the infiltration of CD8+ T cells into the tumor site and boosted anti-tumor immune responses (Wang et al., 2023). The gene discussed is CD8A; the disease is neoplasm.