Another chalcone named 2′, 6′-dihydroxy-4′-methoxychalcone was described to prominently lesser the blood glucose levels in streptozotocin-induced diabetes rats model suppression of enzymes including protein tyrosine phosphatase 1B, α-glucosidase aldose reductase, and increased secretion of insulin (Sudo et al., 2015). Here, PTPN1 is linked to diabetes mellitus.