AKR1B1 and diabetes mellitus: Some of the important enzymes in this pathway are aldose reductase, α-amylase, α-glucosidase, etc. Apart from these enzymes the therapeutic target for the chalcones in control of diabetes also includes Sodium Glucose Cotransporter 2 (SGLT2), Glucose Transporter Type 4 (GLUT4), Peroxisome Proliferator-activated Receptor-gamma (PPAR-γ), Protein Tyrosine Phosphatase 1B (PTP1B), Dipeptidyl Peptidase 4 (DPP-4), and AMPK (Mahapatra et al., 2015a; Rocha et al., 2020).