Another chalcone named 2′, 6′-dihydroxy-4′-methoxychalcone was described to prominently lesser the blood glucose levels in streptozotocin-induced diabetes rats model suppression of enzymes including protein tyrosine phosphatase 1B, α-glucosidase aldose reductase, and increased secretion of insulin (Sudo et al., 2015). The gene discussed is AKR1B1; the disease is diabetes mellitus.