Next, to verify the distinct metabolism patterns in cTfh and Tph cells of RA patients, we measured the levels of GLUT1, HK2, LDH and mtROS in RA CD4+ T cells stimulated with CXCL13 (ligand for CXCR5) or CCL2 (ligand for CCR2). This evidence concerns the gene HK2 and rheumatoid arthritis.