Imiquimod treatment showed effectiveness in inducing memory T cell response, as showed by a progressive increase in CD44+ memory T cells within both CD4+ and CD8+ populations upon two cycles of imiquimod application (recurrent psoriasis-like inflammation), compared to one cycle of imiquimod application (acute psoriasis-like inflammation) (Figure 1A; Supplementary Figure S1A). This evidence concerns the gene CD4 and psoriasis.