Interestingly, SCK vs. NK comparison in SAT samples reveals that during ketosis, most of the genes within the SPINK1 Pancreatic Cancer Pathway relate to AT breakdown and are comparatively upregulated in VAT and downregulated in SAT (Figure 5A), emphasizing depot-specific events of lipid mobilization during SCK. This evidence concerns the gene SHC2 and familial pancreatic carcinoma.