Interestingly, SCK vs. NK comparison in SAT samples reveals that during ketosis, most of the genes within the SPINK1 Pancreatic Cancer Pathway relate to AT breakdown and are comparatively upregulated in VAT and downregulated in SAT (Figure 5A), emphasizing depot-specific events of lipid mobilization during SCK. The gene discussed is SPINK1; the disease is pancreatic neoplasm.