KDM4B and obesity due to melanocortin 4 receptor deficiency: Lastly, the association of the brown module with NK SAT highlighted the histone H3-K36 demethylation as the most overrepresented BP and included the enrichment of KDM4B. The expression of KDM4B in AT is critical for the regulation of systemic metabolism via enhancing energy expenditure in adipocytes (79), as evidenced by its protective effect against obesity and metabolic dysfunction (80).