Regarding the differences in the tumor microenvironment (TME) between the two subtypes, we observed that C2 was rich in the infiltration of several immune cells, such as Activated CD4 T cell, Central memory CD4 T cell, Effector memory CD4 T cell, T follicular helper cell, Type 1 T helper cell, etc. (Figure 2F). The gene discussed is CD4; the disease is neoplasm.