One month later, the patient's genetic report indicated a heterozygous mutation in the HBA1 gene, which was carried in the paternal line, located in Chr16 (GRCh37): g.227115G, C.283G>A, P.AS95ASN, (as Figure 7) which could lead to Titusville-type hemoglobinopathy, the clinical manifestation of which was low-affinity hemoglobinopathy. This evidence concerns the gene HBA1 and hemoglobinopathy.