PRAME and melanoma: These tumors tend to affect a wide age range, with a predilection for adult males, with the most common anatomical location being the deep soft tissues of the limbs or trunk. CIC-rearranged sarcomas have proven not only to be challenging to diagnose but also to treat due to their high resistance to conventional therapies. Preferentially expressed antigen in melanoma (PRAME) is an immunohistochemical stain that was developed primarily for the diagnosis of melanoma and has been shown to also be expressed in other epithelial and mesenchymal tumors.