Tau is very interesting because tau deletion in hAPP mice can protect against hyperexcitability (Roberson et al., 2007; Roth et al., 2024) and selective deletion of tau in a mouse model of Dravet syndrome protects against seizures (Shao et al., 2022). This evidence concerns the gene MAPT and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.