APOE and amyloidosis: Future efforts are warranted to determine whether these effects are age-dependent or are also seen in adult (6-month-old) mice, a time point at which amyloid pathology is seen in NL-G-F (Saito et al., 2014; Holden et al., 2022; Masuda et al., 2016) and NL-G-F/E3 and NL-G-F/E4 mice (Holden et al., 2022) and to include more molecular outcome measures to understand which pathways are affected by KUNV in an apoE isoform-dependent fashion.