Triterpene glycosides from loquat leaves can remodel the mouse gut microbiota by improving insulin resistance, modulating insulin signaling, and inhibiting the cytochrome P450 2E1 (CYP2E1) and NOD‐like receptor family pyrin domain‐containing 3 (NLRP3), ameliorating type 2 diabetes (Chen et al. 2021). This evidence concerns the gene CYP2E1 and Insulin resistance.