Key tumor suppressors, such as p53 and BAP1, promote ferroptosis by repressing the expression of antioxidant defense components like SLC7A11, a subunit of the cystine/glutamate antiporter system Xc− responsible for cystine uptake required for GSH synthesis, and GPX4 [307, 308, 309]. Here, SLC7A11 is linked to neoplasm.