Expression of RHOA G17V encoded by the RHOA mutation and TET2 loss induces T‐cell lymphomas with features of AITL, and the proliferation of such tumor cells is dependent on the activation of inducible co‐stimulator/PI3K/mTOR signaling [361, 362, 379]. The gene discussed is TET2; the disease is angioimmunoblastic T-cell lymphoma.