Molecularly, downregulated TET1 reduces demethylation of the promoter of secreted frizzled‐related protein 2 (SFRP2), an inhibitor of the Wnt/β‐catenin pathway, which represses SFRP2 transcription, activates both classical and nonclassical Wnt signaling pathways, and ultimately leads to epithelial–mesenchymal transition (EMT) in pancreatic cancer [244]. This evidence concerns the gene TET1 and familial pancreatic carcinoma.