An increase in lactate content in the tumor environment significantly increased the occupancy of HIF1A DNA by H3K18la in PC‐3 cells and increased the expression of HIF‐1α and HIF1α‐mediated PD‐L1 while limiting the expression of Sema3A in PCa cells and promoting angiogenesis. Here, SEMA3A is linked to posterior cortical atrophy.