Conversely, evodiamine inhibits PD‐L1 transcription by restricting histone lactylation and the expression of HIF1A in PCa cells while further enhancing Sema3A transcription and inducing iron death by decreasing the expression of glutathione peroxidase 4 (GPX4), which significantly blocks lactic acid‐induced angiogenesis and thus could act as a metabolic epigenetic regulator to exert antitumor effects as an epigenetic regulator of metabolism [181]. This evidence concerns the gene HIF1A and posterior cortical atrophy.