NF-κB signalling in innate immunity is evolutionarily conserved from flies to humans.7-9 Chronic activation of Drosophila NF-κB pathway, so called immune deficiency (Imd), leads to age-dependent neurological decline and neurodegenerative disease.10-13 Given the connection of immunity to neurodegeneration in humans this indicates an evolutionarily conserved path to neurodegenerative disease. This evidence concerns the gene NFKB1 and Immunodeficiency.