EPCAM and infection: We selected this time point as the expansion phase is associated with T3SS activity and effector translocation.15 Deep quantitative proteomic analysis of EpCAM+/CR+ cIECs was performed (Figure 6(a)) and principal component analysis (PCA) revealed distinct clustering between infected and UI mice (PC1, 80.7% variance), with additional separation between CRWT and CRM12 infection (PC2, 5.5% variance) (Figure 6(b)).