However, increasing evidence has identified NLRP3 as a central mediator of excessive inflammation and pyroptosis in the early stages of sepsis.[117] NLRP3 is uniquely activated by a wide range of stimuli, including DAMPs, bacterial toxins, and ATP, making it a central convergence point in the inflammatory cascade.[118] Therefore, the majority of the studies reported so far focused on NLRP3, among various NLRs, as a therapeutic target due to its central role in early inflammation. Here, NLRP3 is linked to Sepsis.