IGSF10 inhibits LUAD cell migration via the Spi-B/Integrin-β1 signaling pathway [51], disrupts normal mesenchymal stromal cell (MSC) differentiation, and induces tumor microenvironment imbalance, and regulation of IGSF10 expression by miR-106b-5p in LUAD tissues emphasizes its role in inhibiting metastasis and invasion, suggesting potential therapeutic interventions [52]. The gene discussed is SPIB; the disease is neoplasm.