GLS and mesothelioma: Adhikary G. et al. conducted a study on mesothelioma, also found that treatment of mesothelioma cells in culture medium with Gln deletion and depletion, the Gln uptake inhibitor V-9302, or the GLS inhibitor CB-839 significantly reduced mesothelioma cell growth by decreasing the level of expression of YAP1, the level of expression of YAP1/TEAD and its target proteins [25].