The risk of developing MetS at age 70 was found to be significantly increased in BDNF rs7103411 heterozygotes (OR = 1.95, P = 0.01), and homozygotes for the minor allele of FTO rs1558902 (OR = 3.07, P = 0.003), with low activity of D5D (OR = 0.05, P = 0.02), high levels of 20:5n-3 (OR = 15.5, P < 0.001), FBG (OR = 1.84, P = 0.01), and AST (OR = 17.7, P < 0.001), low levels of HDL-C (OR = 0.16, P < 0.001), and high levels of apoB (OR = 10.2, P < 0.001). The gene discussed is BDNF; the disease is metabolic syndrome.