Two novel and two pathogenic mutations in COL3A1 gene associated with vEDS, COL1A1, COL1A2, TNXB gene mutations of non-vascular types underlying EDS and COL4A2 gene associated with collagen synthesis were found in patients presenting with pulmonary hemorrhage. The gene discussed is COL1A1; the disease is Ehlers-Danlos syndrome, vascular type.