Chiarelli et al. [23] conducted a transcriptome analysis of skin fibroblasts from patients with vEDS caused by COL3A1. The analysis revealed significant changes in the expression levels of multiple genes involved in cell redox and endoplasmic reticulum homeostasis maintenance, collagen folding and extracellular matrix organization, proteasome complex formation, and cell cycle regulation. Here, COL3A1 is linked to Ehlers-Danlos syndrome, vascular type.