Because neutrophils are a crucial source of key cytokines, including IL-1, IL-6, CXCL8 (also known as IL-8), and GM-CSF, that mediate the inflammatory response in AOSD [55, 56], they are considered to play a leading role in the inflammatory response, influencing both its magnitude and characteristics. Here, CXCL8 is linked to adult-onset Still disease.