Moreover, in the synovial tissue of 12 early (disease duration < 1 year), DMARD-naïve RA patients, previously used by our group [23], SEMA4B expression was elevated in patients who had had persistent disease after 2 years’ follow-up, compared to patients who had self-limiting disease (Fig. 1A). The gene discussed is SEMA4B; the disease is rheumatoid arthritis.