In lenvatinib‐resistant HCC, glycolysis-driven lactate accumulation induces insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) lactylation, transcriptionally maintaining elevated NRF2 and PHDGH levels to activate SSP and strengthen the antioxidant capacity [118]. This evidence concerns the gene IGF2BP3 and hepatocellular carcinoma.