CRP and bacterial infectious disease with sepsis: According to YI, the optimal cut-offs for prediction of bacterial sepsis were 101 mg/l for CRP (sensitivity 56.8%, specificity 74.8%, +LR 2.25, -LR 0.58), 0.27 ng/ml for PCT (sensitivity 65.2%, specificity 77.4%, +LR 2.89, -LR 0.45), 182 μg/ml for HNL (sensitivity 77.4%, specificity 59.0%, +LR 1.89, -LR 0.38), and 12.6 × 109/l for leucocyte count (sensitivity 49.7%, specificity 75.6%, +LR 2.03, -LR 0.67).