In asthma, NFκB is activated in response to inflammatory signals, leading to the degradation of its inhibitory protein, IκBα, and subsequent translocation of NFκB to the nucleus, where it induces the expression of pro-inflammatory cytokines such as granulocyte–macrophage colony-stimulating factor and IL8, which are overexpressed in asthma. The gene discussed is CXCL8; the disease is asthma.