HMOX1 and asthma: For instance, a previous study demonstrated that dexmedetomidine, an α−2-adrenergic receptor agonist, reduced oxidative stress and airway inflammation in a murine asthma model by activating the Nrf2 pathway, which increases the expression of antioxidant genes such as heme oxygenase 1 (HO-1) and glutathione peroxidase 4 [104].