While the differences in lipoprotein profiles (elevated VLDL-C and chylomicron remnants in mice vs. LDL-C/Lp(a)-driven disease in humans) pose translational limitations, the model’s lipid profile (enriched in oxidized VLDL remnants) still activates LOX-1, making it relevant for studying receptor-mediated inflammation, endothelial dysfunction, and foam cell formation.The precise mechanism by which remdesivir modulates ox-LDL-activated LOX-1 remains to be elucidated in upcoming research. Here, OLR1 is linked to endothelial dysfunction.