ATP6V0B serves as a subunit of V-ATPase and mediates eukaryotic intracellular organelles, including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation (Human Protein Atlas) [49], which has been recognized as an essential oncogen in cancer progression by resected tumors and The Cancer Genome Atlas (TCGA) datasets [50]. This evidence concerns the gene ATP6V0B and cancer.