We extracted their gene ontology (Additional file 6), revealing that ExCy discovered marker, ATP6V0B, is a highly relevant EV marker that increases acidification (logFC = 2.02) of the endosomal and Golgi lumen in pancreatic tumors, dysregulating both EV production and cytosolic ion-channel gradients. Here, ATP6V0B is linked to pancreatic neoplasm.