MAPK8 and rheumatoid arthritis: NF-κB and JNK pathways also play the important role in RA, and previous studies have shown that Salvianolic acid A and Isoxanthohumol can improve joint inflammation through NF-κB [16–18], and Pratol affects the NF-κB and JNK pathways [19], Those findings suggest that HT may alleviate RA through these targets and their associated pathways.