MKI67 and urinary bladder carcinoma: In addition, immunohistochemical markers such as HER-2 [39] and Ki-67 [40], as well as indicators like the Systemic Inflammation Response Index (SIRI) [41] and Loss of Y Chromosome (LoY) [42], have been confirmed in previous studies to be closely related to the occurrence, progression, and other processes of bladder cancer, and they possess prognostic value for survival.