In addition, immunohistochemical markers such as HER-2 [39] and Ki-67 [40], as well as indicators like the Systemic Inflammation Response Index (SIRI) [41] and Loss of Y Chromosome (LoY) [42], have been confirmed in previous studies to be closely related to the occurrence, progression, and other processes of bladder cancer, and they possess prognostic value for survival. The gene discussed is ERBB2; the disease is urinary bladder cancer.