Individuals on therapy were more likely than untreated individuals to have clinical features which form part of treatment indications: cirrhosis (39% versus 6·7%, p < 0·001), a higher baseline ALT (median 28 versus 23 IU/L, p < 0·001) and HBeAg positivity (23% versus 3·5%, p < 0·001) (Supplementary Table 4). Here, GPT is linked to Cirrhosis.