RA: rheumatoid arthritis; TNF: tumor necrosis factor; Non-TNF: non tumor necrosis factor; JAK: Janus kinase inhibitors; bDMARD: biological disease-modifying antirheumatic drug; csDMARD: conventional synthetic DMARD; NSAID: nonsteroidal anti-inflammatory drug; CCBs: calcium channel blockers and diuretics; ARBs: angiotensin-receptor blockers, ACEs: angiotensin-converting enzyme. The gene discussed is TNF; the disease is rheumatoid arthritis.