TMC5 and breast cancer: This identified genes that are known to be regulated by STAT3 including those previously reported in an IL-6 dependent gene signature in ER + breast cancer lines (CEBPD, IFITM2, IFITM3, S100A9, TMC5) [43], and some genes that are in the Hallmark IL6-JAK-STAT3 gene set (HMOX1, IL4R, IL13RA1, STAT3, SOCS3).