As shown in Figure S2A, elevated MALAT1 expression was observed in nine tumor tissues compared to normal tissues, including Lung Adenocarcinoma (LUAD), Cholangiocarcinoma (CHOL), Colon Adenocarcinoma (COAD), Head and Neck Squamous Cell Carcinoma (HNSC), etc. We further investigated GTEx dataset for normal tissues using the GEPIA2 tool (Figure S2B), we found significant upregulation of MALAT1 expression in four tumors, such as CHOL, Esophageal Carcinoma (ESCA), Acute Myeloid Leukemia (LAML), and Stomach Adenocarcinoma (STAD). The gene discussed is MALAT1; the disease is head and neck squamous cell carcinoma.