TARDBP and Alzheimer disease: In addition to prion diseases, a group of neurodegenerative pathologies commonly called prion-like disorders are characterised by the accumulation of protein aggregates, such as beta-amyloid and tau in Alzheimer’s disease (AD), alpha-synuclein in Parkinson’s disease (PD) and SOD1 and TDP-43 in amyotrophic lateral sclerosis (ALS) [4, 5].