Although there are no previous studies of miR-425 in prion diseases, our significant finding of the upregulation of miR-425 in the blood and CNS of scrapie sheep, alongside its reported upregulation in AD blood and association with tau phosphorylation [65, 74], further supports its involvement in neurotoxic protein aggregation and neurodegeneration. The gene discussed is MAPT; the disease is scrapie.