Additionally, interactions between EDNRB and other signaling pathways, such as the C-X3-C motif chemokine ligand 1 (CX3CL1)/C-X3-C motif chemokine receptor 1 (CX3CR1) axis in experimental hepatopulmonary syndrome, underscore the need for caution in therapeutic targeting [121]. The gene discussed is CX3CL1; the disease is hepatopulmonary syndrome.