Tumor-derived ceramide species (such as C16, C24:1, and C24:0) have also been shown to induce apoptosis in DCs by inhibiting survival pathways like phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and extracellular signal-regulated kinase (ERK) (Fig. 2) [9, 114, 115]. Here, AKT1 is linked to neoplasm.