Consequently, when GSN cleavage occurs in the extracellular space, it may lead to pathological conditions caused by extracellular actin, such as endothelial damage, respiratory distress syndrome, liver necrosis, or septic shock [35]. Future studies should focus on the influence of cleaved forms of GSN present in the ECM on melanoma cells. The gene discussed is GSN; the disease is newborn respiratory distress syndrome.