Unfortunately, specific antibodies recognizing individual isoforms of GSN are not available; therefore, to determine the nature of the effects of selected isoforms of GSN on melanoma cell biology, cell clones were obtained from GSN-deprived (KO GSN) A375 cells [23] that exogenously produced only the protein's A, B, or C isoform—OE GSN-A, OE GSN-B, and OE GSN-C cell clones. The gene discussed is GSN; the disease is melanoma.