AKT1 and polycystic ovary syndrome: Recent network pharmacology analyses have shown that TCM formulas such as Guizhi Fuling Wan regulated more than 120 PCOS-related targets, influencing pathways such as PI3K/AKT insulin signaling [32, 33], NLRP3 inflammasome activation, and autophagy via the H19/miR-29b-3p axis [34].