While baseline IFN-γ production and signaling appear to support memory function as shown in reports providing evidence for a neuroprotective effect under normal conditions [13], an up-regulated, chronic IFN-γ production under neuroinflammatory and pathological conditions, as found for example in neurodegenerative diseases, seems to result in deleterious effects [9]. This evidence concerns the gene IFNG and neurodegenerative disease.