Among the most significantly down-regulated genes, ubiquitin-specific protease 18 (Usp18), IFN-induced protein 44 (Ifi44), 2’-5’-oligoadenylate synthetase 2 (Oas2), 2’-5’-oligoadenylate synthetase-like 2 (Oasl2) and galectin-3-binding protein (Lgals3bp) were found, which all code for proteins essentially involved in the innate immune response to viral infection. This evidence concerns the gene USP18 and viral infectious disease.