Interestingly, gene set enrichment analysis (GSEA) showed a reduction of the peroxisomal gene signature in HeLa cells upon RNF20 or RNF40 KD, but also in the TCGA-CESC patient cohort with concomitant low RNF20/RNF40 expression score (Fig. 3C-F). The gene discussed is RNF20; the disease is cervical squamous cell carcinoma.