We investigated the role of RNF20 and RNF40 in cervical cancer cells by leveraging paraffin-embedded IHC staining on patient material, in vitro functional assays, in vivo CAM assays, flow cytometry, various microscopy-based techniques, ChIP-qPCR, as well as genome-wide transcriptome analysis from cell lines and publicly available datasets. Here, RNF20 is linked to cervical carcinoma.