Finally, Type 4 (n = 253, 9.0%) is characterized by a very high utilization of MHC throughout the period of interest, mainly for SSD (Figs. 2 and 3), while Type 5 (n = 100, 3.6%) is also characterized by a high utilization of MHC, but mainly for bipolar disorder. The gene discussed is HLA-C; the disease is bipolar disorder.